| Autor: |
Adam-Bonci TI; Pathophysiology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; 3rd Pediatrics Clinic, Children's Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania., Cherecheș-Panța P; 3rd Pediatrics Clinic, Children's Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania.; 3rd Pediatrics Clinic, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania., Bonci EA; Oncological Surgery and Gynecologic Oncology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania., Man SC; 3rd Pediatrics Clinic, Children's Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania.; 3rd Pediatrics Clinic, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania., Cutaș-Benedec A; Medical Informatics and Biostatistics, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Drugan T; Medical Informatics and Biostatistics, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Pop RM; Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania., Irimie A; Oncological Surgery and Gynecologic Oncology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania. |
| Abstrakt: |
Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D 3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month ( p = 0.02). Even under seasonal oral vitamin D 3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D 3 status in regard to asthma, especially in symptomatic patients. |
