Mechanisms Targeting the Unfolded Protein Response in Asthma.

Autor:	Dastghaib S; Department of Clinical Biochemistry and.; Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran., Kumar PS; National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Aftabi S; Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine.; Medical Physics Department and., Damera G; Personalized and Predictive Medicine (Respiratory), Global Research and Development, Teva Pharmaceuticals, Malvern, Pennsylvania., Dalvand A; Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine., Sepanjnia A; Department of Immunology, School of Medicine, Jiroft University of Medical Science, Jiroft, Iran., Kiumarsi M; Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine., Aghanoori MR; Department of Human Genetics, School of Medicine, and.; Department of Pharmacology and Therapeutics.; Division of Neurodegenerative Disorders, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, Manitoba, Canada., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia., Ande SR; Department of Internal Medicine, and., Alizadeh J; Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine.; Research Institute of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, Manitoba, Canada., Mokarram P; Department of Clinical Biochemistry and.; Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran., Ghavami S; Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine.; Department of Internal Medicine, and.; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada., Sharma P; Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania., Zeki AA; Lung Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, California; and.; Veterans Affairs Medical Center, Mather, California.
Jazyk:	angličtina
Zdroj:	American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Jan; Vol. 64 (1), pp. 29-38.
DOI:	10.1165/rcmb.2019-0235TR
Abstrakt:	Lung cells are constantly exposed to various internal and external stressors that disrupt protein homeostasis. To cope with these stimuli, cells evoke a highly conserved adaptive mechanism called the unfolded protein response (UPR). UPR stressors can impose greater protein secretory demands on the endoplasmic reticulum (ER), resulting in the development, differentiation, and survival of these cell types to meet these increasing functional needs. Dysregulation of the UPR leads to the development of the disease. The UPR and ER stress are involved in several human conditions, such as chronic inflammation, neurodegeneration, metabolic syndrome, and cancer. Furthermore, potent and specific compounds that target the UPR pathway are under development as future therapies. The focus of this review is to thoroughly describe the effects of both internal and external stressors on the ER in asthma. Furthermore, we discuss how the UPR signaling pathway is activated in the lungs to overcome cellular damage. We also present an overview of the pathogenic mechanisms, with a brief focus on potential strategies for pharmacological interventions.
Databáze:	MEDLINE
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