Effects of ovariectomy on inputs from the medial preoptic area to the ventromedial nucleus of the hypothalamus of young adult rats.

Autor:	Pereira LDS; Laboratorio de Neuroanatomia Quimica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, São Paulo, Brazil., Gobbo DR; Laboratorio de Neuroanatomia Quimica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, São Paulo, Brazil., Ferreira JGP; Laboratorio de Neuroanatomia Quimica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, São Paulo, Brazil., Horta-Junior JACE; Departamento de Biologia Estrutural e Funcional - Setor de Anatomia, Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, Botucatu, Brazil., Sá SI; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Medicine, CINTESIS, Centre for Health Technology and Services Research, University of Porto, Porto, Portugal., Bittencourt JC; Laboratorio de Neuroanatomia Quimica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, São Paulo, Brazil.; Nucleo de Neurociencias e Comportamento, Instituto de Psicologia, Universidade de Sao Paulo, Sao Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of anatomy [J Anat] 2021 Feb; Vol. 238 (2), pp. 467-479. Date of Electronic Publication: 2020 Sep 11.
DOI:	10.1111/joa.13304
Abstrakt:	Puberty is an important phase of development when the neural circuit organization is transformed by sexual hormones, inducing sexual dimorphism in adult behavioural responses. The principal brain area responsible for the control of the receptive component of female sexual behaviour is the ventrolateral division of the ventromedial nucleus of the hypothalamus (VMHvl), which is known for its dependency on ovarian hormones. Inputs to the VMHvl originating from the medial preoptic nucleus (MPN) are responsible for conveying essential information that will trigger such behaviour. Here, we investigated the pattern of the projection of the MPN to the VMHvl in rats ovariectomized at the onset of puberty. Sprague Dawley rats were ovariectomized (OVX) at puberty and then subjected to iontophoretic injections of the neuronal anterograde tracer Phaseolus vulgaris leucoagglutinin into the MPN once they reached 90 days of age. This study analysed the connectivity pattern established between the MPN and the VMH that is involved in the neuronal circuit responsible for female sexual behaviour in control and OVX rats. The data show the changes in the organization of the connections observed in the OVX adult rats that displayed a reduced axonal length for the MPN fibres reaching the VMHvl, suggesting that peripubertal ovarian hormones are relevant to the organization of MPN connections with structures involved in the promotion of female sexual behaviour. (© 2020 Anatomical Society.)
Databáze:	MEDLINE
Externí odkaz:	Plný text