Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD.

Autor: Lehti M; Faculty of Sport and Health Science, University of Jyväskylä Jyväskylä, Finland.; LIKES Research Centre for Physical Activity and Health Jyväskylä, Finland., Valkeinen H; Finnish Institute for Health and Welfare Helsinki, Finland., Sipilä S; Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä Jyväskylä, Finland., Perhonen M; Suomen Terveystalo Oyj Jyväskylä, Finland., Rottensteiner M; Faculty of Sport and Health Science, University of Jyväskylä Jyväskylä, Finland.; Department of Medicine, Central Finland Health Care District Jyväskylä, Finland., Pullinen T; Neuromuscular Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä Jyväskylä, Finland., Pietiläinen R; Lapland University of Applied Sciences Kemi, Finland., Nyman K; Central Hospital of Central Finland Jyväskylä, Finland., Vehkaoja A; Faculty of Medicine and Health Technology, Tampere University Tampere, Finland., Kainulainen H; Neuromuscular Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä Jyväskylä, Finland., Kujala UM; Faculty of Sport and Health Science, University of Jyväskylä Jyväskylä, Finland.
Jazyk: angličtina
Zdroj: American journal of translational research [Am J Transl Res] 2020 Aug 15; Vol. 12 (8), pp. 4582-4593. Date of Electronic Publication: 2020 Aug 15 (Print Publication: 2020).
Abstrakt: This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO 2peak ), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO 2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.
Competing Interests: None.
(AJTR Copyright © 2020.)
Databáze: MEDLINE
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