Two new chemical constituents from the rhizomes of Actaea dahurica .

Autor: Ma SJ; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China., Li HB; Jiangsu Kanion Pharmaceutical Co. Ltd. and State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu, Lianyungang, China., Shao JR; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China., Pang QQ; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China., Li T; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China., Yao XS; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China., Yu Y; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2022 Apr; Vol. 36 (7), pp. 1789-1796. Date of Electronic Publication: 2020 Sep 11.
DOI: 10.1080/14786419.2020.1817016
Abstrakt: A new phenylpropanoid allopyranoside ( 1 ) and a new indolinone alkaloid ( 2 ) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica ). The structures of those two compounds were deduced as cimicifugaside F ( 1 ) and 3 E ,11 E -(3-methyl-2-butenylidene acid)-2-indolinone-1- O - β -d-glucopyranoside ( 2 ) by detailed analysis of their MS, 1D and 2D NMR data and comparison with literatures. Additionally, the isolates were evaluated for their inhibitory effects on the production of NO by LPS-stimulated RAW 264.7 macrophages.
Databáze: MEDLINE
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