Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT.

Autor: Inglis JE; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Fernandez ID; Department of Public Health Sciences, University of Rochester Medical Center (URMC), Rochester, New York, USA., van Wijngaarden E; Department of Public Health Sciences, University of Rochester Medical Center (URMC), Rochester, New York, USA., Culakova E; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Reschke JE; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Kleckner AS; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Lin PJ; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Mustian KM; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA., Peppone LJ; Department of Surgery, University of Rochester Medical Center (URMC), Rochester, New York, USA.
Jazyk: angličtina
Zdroj: Nutrition and cancer [Nutr Cancer] 2021; Vol. 73 (10), pp. 1882-1889. Date of Electronic Publication: 2020 Sep 11.
DOI: 10.1080/01635581.2020.1819348
Abstrakt: Purpose: Androgen deprivation therapy (ADT) is commonly used to treat patients with advanced prostate cancer but is associated with functional decline. Bioelectrical impedance analysis (BIA)-derived phase angle may reflect frailty and functional decline in cancer patients. High-dose vitamin D supplementation may improve phase angle values and physical function.
Methods: We conducted an exploratory analysis from a phase II randomized controlled trial investigating the efficacy of high-dose vitamin D supplementation in prostate cancer patients (age ≥ 60 yrs). Fifty-nine patients were randomized to high-dose vitamin D (600 IU/day plus 50,000 IU/week) or low-dose: RDA for vitamin D (600 IU/day plus placebo weekly) for 24 weeks. Phase angle was measured by BIA. Physical function measures included handgrip strength, 6-minute walk test, Short Performance Physical Battery and leg extension. All testing was completed at baseline, week 12 and week 24.
Results: Phase angle values were wider over the entire study in the high-dose vitamin D arm indicating healthier muscle cells. The low-dose vitamin D arm had phase angle values consistent with frailty cutoffs in older men (<5.7°).
Conclusion: Patients in the high-dose vitamin D arm experienced wider phase angle values over the course of the study which may indicate less frailty. ClinicalTrials.gov ID: NCT02064946.
Databáze: MEDLINE
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