Dengue infection modulates locomotion and host seeking in Aedes aegypti.

Autor: Tallon AK; Disease Vector Group, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden., Lorenzo MG; Vector Behaviour and Pathogen Interaction Group, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Moreira LA; Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou-Fiocruz, Belo Horizonte, Minas Gerais, Brazil., Martinez Villegas LE; Vector Behaviour and Pathogen Interaction Group, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Hill SR; Disease Vector Group, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden., Ignell R; Disease Vector Group, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Sep 10; Vol. 14 (9), pp. e0008531. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
DOI: 10.1371/journal.pntd.0008531
Abstrakt: Pathogens may manipulate their human and mosquito hosts to enhance disease transmission. Dengue, caused by four viral serotypes, is the fastest-growing transmissible disease globally resulting in 50-100 million infections annually. Transmission of the disease relies on the interaction between humans and the vector Aedes aegypti and is largely dependent on the odor-mediated host seeking of female mosquitoes. In this study, we use activity monitors to demonstrate that dengue virus-1 affects the locomotion and odor-mediated behavior of Ae. aegypti, reflecting the progression of infection within the mosquito. Mosquitoes 4-6 days post-infection increase locomotion, but do not alter their odor-driven host-seeking response. In contrast, females 14-16 days post-infection are less active, yet more sensitive to human odors as assessed by behavioral and electrophysiological assays. Such an increase in physiological and behavioral sensitivity is reflected by the antennal-specific increase in abundance of neural signaling transcripts in 14 days post-infection females, as determined by transcriptome analysis. This suggests that the sensitivity of the mosquito peripheral olfactory system is altered by the dengue virus by enhancing the overall neural responsiveness of the antenna, rather than the selective regulation of chemosensory-related genes. Our study reveals that dengue virus-1 enhances vector-related behaviors in the early stages post-infection that aid in avoiding predation and increasing spatial exploration. On the other hand, at the later stages of infection, the virus enhances the host-seeking capacity of the vector, thereby increasing the risk of virus transmission. A potential mechanism is discussed.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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