Morphological Characteristics of the Action of Cationic Peptide Warnerin on Regeneration of the Connective Tissue around Implanted Teflon Catheters in Mice under Conditions of Immunosuppression.

Autor: Litvinov VV; E. A. Wagner Perm' State Medical University, Ministry of Health of the Russian Federation, Perm', Russia. drlitvinov@mail.ru., Lemkina LM; Institute of Ecology and Microorganic Genetics, Ural Division of Russian Academy of Sciences, Perm', Russia., Freund GG; E. A. Wagner Perm' State Medical University, Ministry of Health of the Russian Federation, Perm', Russia., Korobov VP; Institute of Ecology and Microorganic Genetics, Ural Division of Russian Academy of Sciences, Perm', Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Aug; Vol. 169 (4), pp. 521-524. Date of Electronic Publication: 2020 Sep 10.
DOI: 10.1007/s10517-020-04922-6
Abstrakt: Warnerin pretreatment of catheter segments subcutaneously implanted to mice under conditions of immunosuppression led to a significant increase in the number of neutrophils in the surrounding tissues on day 1; the number of fibroblasts tended to decrease by day 3. Immunohistochemical study showed the presence of T and B lymphocytes on day 3, but no positive reactions to vimentin and CD34 were observed during the first 2 days. These changes suggest that warnerin reduced the intensity of regeneration processes in tissues around the implant, which can be used for suppression of fibrosis.
Databáze: MEDLINE
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