Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion.

Autor:	Cioni B; Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Zaalberg A; Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., van Beijnum JR; Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Melis MHM; Molecular Genetics, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., van Burgsteden J; Molecular Genetics, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Muraro MJ; Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands., Hooijberg E; Division of Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Peters D; Core Facility Molecular Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Hofland I; Core Facility Molecular Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Lubeck Y; Division of Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., de Jong J; Division of Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Sanders J; Division of Pathology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Vivié J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands., van der Poel HG; Urology and Medical Oncology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., de Boer JP; Urology and Medical Oncology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands., Griffioen AW; Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Zwart W; Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. w.zwart@nki.nl.; Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600MB, Eindhoven, The Netherlands. w.zwart@nki.nl.; Oncode Institute, The Netherlands. w.zwart@nki.nl., Bergman AM; Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. a.bergman@nki.nl.; Urology and Medical Oncology, NKI, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. a.bergman@nki.nl.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2020 Sep 09; Vol. 11 (1), pp. 4498. Date of Electronic Publication: 2020 Sep 09.
DOI:	10.1038/s41467-020-18313-y
Abstrakt:	The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy.
Databáze:	MEDLINE
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