Oxaliplatin-associated sarcoid-like reaction masquerading as recurrent colon cancer.
| Autor: | Aedma SK; Internal Medicine, Carle Foundation Hospital, Urbana, Illinois, USA., Chidharla A; Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA., Kelting S; Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA., Kasi A; Medical Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA anupdoc@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2020 Sep 08; Vol. 13 (9). Date of Electronic Publication: 2020 Sep 08. |
| DOI: | 10.1136/bcr-2019-229548 |
| Abstrakt: | A 54-year-old man with stage IV B metastatic colorectal cancer with liver and peritoneal metastasis was treated with cytoreductive surgery (extended left colectomy, right partial hepatectomy, resection of right diaphragm nodule) and perioperative oxaliplatin-based chemotherapy. The patient was cancer-free for 6 months, at which point a surveillance positron emission tomography-CT scan showed metabolically active hepatosplenic lesions and mediastinal and bilateral hilar lymph nodes. An endobronchial ultrasound bronchoscopy-guided fine needle aspiration of the mediastinal and hilar lymph nodes revealed non-necrotising granulomas. The workup was negative for bacterial, fungal or mycobacterial infection, cancer or autoimmune disease. Carcinoembryonic antigen and COLVERA (a circulating tumour DNA liquid biopsy test for the detection of recurrent colon cancer) tests were negative. Subsequently the rare diagnosis of a sarcoidosis-like reaction from oxaliplatin-based chemotherapy was made. Repeat imaging after 3 months showed resolution of the hepatosplenic lesions and lymphadenopathy, alike. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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