Hyperresistinemia in Obese Female Dogs With Mammary Carcinoma in Benign-Mixed Tumors and Its Correlation With Tumor Aggressiveness and Survival.

Autor:	Nicchio BO; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil., Barrouin-Melo SM; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil., Machado MC; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil., Vieira-Filho CH; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil., Santos FL; Health Science Center, Federal University of the Recôncavo of Bahia, Santo Antônio de Jesus, Brazil., Martins-Filho EF; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil., Barbosa VF; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil., Barral TD; Laboratory of Immunology and Molecular Biology, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Portela RW; Laboratory of Immunology and Molecular Biology, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil., Damasceno KA; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil.; Laboratory of Experimental Pathology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil., Estrela-Lima A; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV/UFBA, Salvador, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2020 Aug 13; Vol. 7, pp. 509. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
DOI:	10.3389/fvets.2020.00509
Abstrakt:	Resistin is associated with metabolic, inflammatory, and neoplastic disorders, and is also considered a prognostic marker in human oncology. Canine mammary tumors have epidemiological, clinical, biological, and genetic characteristics similar to those of women and are proposed as a comparative study model. Here, we evaluate the serum levels of resistin in female dogs with or without mammary carcinoma in mixed tumors (CBMT) and its correlation with the proliferative potential of the tumor, obesity, and survival. Eighty dogs grouped according to the presence (50) or absence (30) of CBMT, reproductive status and body condition were assessed for weight, fat percentage, and canine body mass index. The characteristic of the proliferative potential of the tumor (Ki-67) was evaluated. Ki-67 levels ( p = 0.024), staging ( p = 0.004), and grade ( p = 0.016) influenced the survival of the female dogs. Through a multifactorial analysis, it could be seen that the parameters proliferation index (Ki-67) ( p = 0.044) and staging ( p = 0.036) influenced the survival of the animals. Neutered and overweight dogs from the control and CBMT groups showed hyperresistinemia. Ki-67 expression and resistin levels in dogs with CBMT were higher in overweight dogs than in dogs with normal weight ( p = 0.0001). The survival rate of dogs with CBMT, obese and with high levels of resistin (8,400 μg L -1 ) was lower when compared to those with lower levels of resistin. These results showed an important relationship between hyperresistinemia, tumor proliferative potential and excessive body fat, suggesting that resistin levels may act as an interesting prognostic marker in patients with CBMT. (Copyright © 2020 Nicchio, Barrouin-Melo, Machado, Vieira-Filho, Santos, Martins-Filho, Barbosa, Barral, Portela, Damasceno and Estrela-Lima.)
Databáze:	MEDLINE
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