Long ascending propriospinal neurons provide flexible, context-specific control of interlimb coordination.

Autor:	Pocratsky AM; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States., Shepard CT; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States., Morehouse JR; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Department of Neurological Surgery, University of Louisville, Louisville, United States., Burke DA; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Department of Neurological Surgery, University of Louisville, Louisville, United States., Riegler AS; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Department of Neurological Surgery, University of Louisville, Louisville, United States., Hardin JT; Speed School of Engineering, University of Louisville, Louisville, United States., Beare JE; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Cardiovascular Innovation Institute, Department of Physiology and Biophysics, University of Louisville, Louisville, United States., Hainline C; Speed School of Engineering, University of Louisville, Louisville, United States., States GJ; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States., Brown BL; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States., Whittemore SR; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Department of Neurological Surgery, University of Louisville, Louisville, United States., Magnuson DS; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, United States.; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, United States.; Department of Neurological Surgery, University of Louisville, Louisville, United States.; Speed School of Engineering, University of Louisville, Louisville, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2020 Sep 09; Vol. 9. Date of Electronic Publication: 2020 Sep 09.
DOI:	10.7554/eLife.53565
Abstrakt:	Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, ensuring that diagonal limb pairs move synchronously while the ipsilateral limb pairs move out-of-phase during stepping. Here, we show that silencing long ascending propriospinal neurons (LAPNs) that inter-connect the lumbar and cervical CPGs disrupts left-right limb coupling of each limb pair in the adult rat during overground locomotion on a high-friction surface. These perturbations occurred independent of the locomotor rhythm, intralimb coordination, and speed-dependent (or any other) principal features of locomotion. Strikingly, the functional consequences of silencing LAPNs are highly context-dependent; the phenotype was not expressed during swimming, treadmill stepping, exploratory locomotion, or walking on an uncoated, slick surface. These data reveal surprising flexibility and context-dependence in the control of interlimb coordination during locomotion. Competing Interests: AP, CS, JM, DB, AR, JH, JB, CH, GS, BB, SW, DM No competing interests declared (© 2020, Pocratsky et al.)
Databáze:	MEDLINE
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