| Autor: |
Lima NM; Department of Organic Chemistry, Institute of Chemistry, Nucleus of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University UNESP, Araraquara, Sao Paulo, Brazil., de Marqui SR; Department of Organic Chemistry, Institute of Chemistry, Nucleus of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University UNESP, Araraquara, Sao Paulo, Brazil., Andrade TJAS; Nucleus of Applied Research to Sciences (NIAC), Federal Institute of Maranhão, Maranhão, Brazil., Silva DHS; Department of Organic Chemistry, Institute of Chemistry, Nucleus of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University UNESP, Araraquara, Sao Paulo, Brazil. |
| Abstrakt: |
Natural Products phytochemical provide a rich source for therapeutic discovery and has led to the development of many drugs. Thus, the aim of this study was to obtaining a metabolic profiling from ethanol extract of Inga semialata leaves (EEIS) selected by bioassay antimalarial and nematostatic and identify metabolites in mixture by co-injection experiments and NMR spectroscopy. The chemical composition of this species indicated a wide variety of aromatic acids (vanillic acid, 3,4,5-trimethoxy benzoic acid, gallic acid, methyl gallate , p -coumaric acid and ferulic acid), flavonoids (quercetin, myricetin-3- O - rhamnoside and myricetin-3- O -(2"-O- galloyl )- α -rhamnopyranoside), triterpenes (lupeol, α -amyrin, friedelin and oleanolic acid) and the 2-hydroxyethyl-dodecanoate. The antimalarial assay showed that the I. semialata n- hexane fraction presented higher inhibition percentage than the Chloroquine standard and may be considered a potential source of compounds with antimalarial activity while the EEIS and its fractions showed nematostatic potential below 17% in the assay of nematostatic evaluation against the parasite Meloidogyne incognita . |
