The emergence of hypervirulent bla NDM-1 -positive Klebsiella pneumoniae sequence type 395 in an oncology hospital.

Autor: Lazareva I; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia., Ageevets V; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia., Sopova J; Saint Petersburg University, Universitetskaya Emb. 13B, Saint Petersburg 199034, Russia., Lebedeva M; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia., Starkova P; National Research Institute of Information Technologies, Mechanics and Optics, Lomonosova Str. 9, Saint Petersburg 191002, Russia., Likholetova D; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; Saint Petersburg University, Universitetskaya Emb. 13B, Saint Petersburg 199034, Russia., Lebedeva M; Bryansk Interregional Veterinary Laboratory, Suponevo, Shosseynaya Str. 7, Bryansk 241520, Russia., Gostev V; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia., Moiseenko V; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia., Egorenkov V; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia., Navatskaya A; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia., Mitroshina G; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia., Myasnikova E; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia., Tsvetkova I; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia., Lobzin Y; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia., Sidorenko S; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia. Electronic address: sidorserg@niidi.ru.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2020 Nov; Vol. 85, pp. 104527. Date of Electronic Publication: 2020 Sep 06.
DOI: 10.1016/j.meegid.2020.104527
Abstrakt: Fifteen hypermucoviscous isolates (13 bla NDM-1 -positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD 50  = 10 2  CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD 50  = 10 4  CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD 50  = 10 5  CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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