The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic.
| Autor: | Rothan HA; Department of Biology, College of Arts and Sciences, Georgia State University, GA, USA., Byrareddy SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Centre, Omaha, NE, USA.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, NE, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2021 Jan; Vol. 32 (1), pp. 17-22. Date of Electronic Publication: 2020 Oct 13. |
| DOI: | 10.1111/pai.13361 |
| Abstrakt: | Multisystem inflammatory syndrome in children (MIS-C) during the COVID-19 pandemic raised a global alert from the Centers for Disease Control and Prevention's Health Alert Network. The main manifestations of MIS-C (also known as pediatric MIS (PMIS)) in the setting of a severe inflammatory state include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes. In some cases, these symptoms progressed to multi-organ failure. The low percentage of children with asymptomatic cases compared with mild illness and moderate illness could be correlated with the rare cases of MIS-C. One potential explanation for the progression to severe MIS-C disease despite the presence of readily detectable anti-SARS-CoV-2 antibodies could be due to the potential role of antibody-dependent enhancement (ADE). We reason that the incidence of the ADE phenomenon whereby the pathogen-specific antibodies can promote pathology should be considered in vaccine development against SARS-CoV-2. (© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.) |
| Databáze: | MEDLINE |
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