Inflammation in Huntington's disease: A few new twists on an old tale.

Autor:	Valadão PAC; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: drapriscilavaladao@gmail.com., Santos KBS; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Ferreira E Vieira TH; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Departamento de Fisioterapia, Faculdade Sete Lagoas, Sete Lagoas, MG, Brazil., Macedo E Cordeiro T; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Belo Horizonte, Minas Gerais, Brazil., Teixeira AL; Santa Casa BH Ensino e Pesquisa, Belo Horizonte, Brazil; Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Guatimosim C; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., de Miranda AS; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Belo Horizonte, Minas Gerais, Brazil. Electronic address: mirandaas@icb.ufmg.br.
Jazyk:	angličtina
Zdroj:	Journal of neuroimmunology [J Neuroimmunol] 2020 Nov 15; Vol. 348, pp. 577380. Date of Electronic Publication: 2020 Aug 31.
DOI:	10.1016/j.jneuroim.2020.577380
Abstrakt:	Huntington's disease (HD) is a neurodegenerative disease characterized by prominent loss of neurons in the striatum and cortex. Traditionally research in HD has focused on brain changes as they cause progressive motor dysfunction, cognitive decline and psychiatric disorders. The discovery that huntingtin protein (HTT) and its mutated form (mHTT) are expressed not only in the brain but also in different organs and tissues paved the way for the hypothesis that HD might affect regions beyond the central nervous system (CNS). Besides pathological deposition of mHTT, other mechanisms, including inflammation, seem to underlie HD pathogenesis and progression. Altered inflammation can be evidenced even before the onset of classical symptoms of HD. Herein, we will discuss current pre-clinical and clinical evidence on immune/inflammatory changes in peripheral organs during HD development and progression. The understanding of the impact of inflammation on peripheral organs may open new venues for the development of novel therapeutic targets in HD. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Full Text from ScienceDirect