The Influence of the Cholesterol Level in Cells on Endovanilloid Cytotoxicity.

Autor: Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. akimovmike@gmail.com., Dudina PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Gamisonia AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Zinchenko GN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Mandal CC; School of Life Sciences, Central University of Rajasthan, NH 8, Bandarsindri, 305817, Ajmer, Kishangarh, Rajasthan, India., Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Jul; Vol. 493 (1), pp. 167-170. Date of Electronic Publication: 2020 Sep 07.
DOI: 10.1134/S1607672920040018
Abstrakt: The influence of the cellular cholesterol content on the cytotoxicity of endovanilloids acyldopamines was studied in MDA-MB-231 and MCF 10A cells. The activity of acyldopamines depends on the cellular cholesterol content, and a decrease in cholesterol content increases the cytotoxicity of acyldopamines.
Databáze: MEDLINE
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