A limbic circuit selectively links active escape to food suppression.

Autor:	Azevedo EP; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Tan B; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Pomeranz LE; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Ivan V; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Fetcho R; Department of Psychiatry, Weill Cornell Medical College-New York Presbyterian Hospital, New York, United States., Schneeberger M; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Doerig KR; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States., Liston C; Department of Psychiatry, Weill Cornell Medical College-New York Presbyterian Hospital, New York, United States., Friedman JM; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States.; Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Stern SA; Laboratory of Molecular Genetics, The Rockefeller University, New York, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2020 Sep 07; Vol. 9. Date of Electronic Publication: 2020 Sep 07.
DOI:	10.7554/eLife.58894
Abstrakt:	Stress has pleiotropic physiologic effects, but the neural circuits linking stress to these responses are not well understood. Here, we describe a novel population of lateral septum neurons expressing neurotensin (LS Nts ) in mice that are selectively tuned to specific types of stress. LS Nts neurons increase their activity during active escape, responding to stress when flight is a viable option, but not when associated with freezing or immobility. Chemogenetic activation of LS Nts neurons decreases food intake and body weight, without altering locomotion and anxiety. LS Nts neurons co-express several molecules including Glp1r (glucagon-like peptide one receptor) and manipulations of Glp1r signaling in the LS recapitulates the behavioral effects of LS Nts activation. Activation of LS Nts terminals in the lateral hypothalamus (LH) also decreases food intake. These results show that LS Nts neurons are selectively tuned to active escape stress and can reduce food consumption via effects on hypothalamic pathways. Competing Interests: EA, BT, LP, VI, RF, MS, KD, CL, JF, SS No competing interests declared (© 2020, Azevedo et al.)
Databáze:	MEDLINE
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