Applying Non-canonical Redox Cofactors in Fermentation Processes.

Autor:	Weusthuis RA; Bioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the Netherlands., Folch PL; Bioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the Netherlands., Pozo-Rodríguez A; Bioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the Netherlands., Paul CE; Biocatalysis, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2020 Aug 18; Vol. 23 (9), pp. 101471. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).
DOI:	10.1016/j.isci.2020.101471
Abstrakt:	Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via redox cofactors results in a diffuse distribution of electrons over metabolism. To overcome this challenge, we propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer. (© 2020 The Author(s).)
Databáze:	MEDLINE
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