Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study.

Autor: Sabapathy D; University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Klawitter J; University of Colorado Denver Department of Anesthesiology, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Silveira L; University of Colorado Denver Department of Biostatistics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Khailova L; Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Mitchell MB; University of Colorado Denver Department of Surgery, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Morgan GJ; Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., DiMaria MV; Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Twite M; University of Colorado Denver Department of Anesthesiology, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Frank BS; Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA., Davidson JA; Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. jesse.davidson@childrenscolorado.org.
Jazyk: angličtina
Zdroj: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2020 Sep 05; Vol. 16 (9), pp. 93. Date of Electronic Publication: 2020 Sep 05.
DOI: 10.1007/s11306-020-01714-x
Abstrakt: Background: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed.
Aims: To map changes in the KP induced by infant CPB.
Methods: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry.
Results: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP.
Conclusions: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.
Databáze: MEDLINE
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