High-density lipoprotein-related cholesterol metabolism in Alzheimer's disease.

Autor: Pedrini S; Sarich Neurosciences Research Institute, Edith Cowan University, Nedlands, WA, Australia., Chatterjee P; Sarich Neurosciences Research Institute, Edith Cowan University, Nedlands, WA, Australia.; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Hone E; Sarich Neurosciences Research Institute, Edith Cowan University, Nedlands, WA, Australia., Martins RN; Sarich Neurosciences Research Institute, Edith Cowan University, Nedlands, WA, Australia.; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, WA, Australia.
Jazyk: angličtina
Zdroj: Journal of neurochemistry [J Neurochem] 2021 Oct; Vol. 159 (2), pp. 343-377. Date of Electronic Publication: 2020 Oct 27.
DOI: 10.1111/jnc.15170
Abstrakt: High-density lipoproteins (HDL) are a heterogeneous class of molecules whose main function is to remove excess cholesterol through a mechanism called reverse transport, in which cholesterol is transported from peripheral organs and from arterial foam cells to the liver, where it is subsequently eliminated with bile. While its ability to eliminate excess cholesterol has always been viewed as its main feature, its beneficial effects go beyond this single effect. Many of the proteins that are associated with HDL are responsible for anti-oxidant and anti-inflammatory properties. These proteins that are associated with HDL during its generation and remodelling, are referred to as 'protein cargo', which has been extensively analysed by mass spectrometry analysis in healthy and diseased individuals. In this review, we discuss the pathway that leads to HDL formation and its subsequent remodelling and catabolism with regards to the possible involvement of HDL 'protein cargo' in Alzheimer's disease.
(© 2020 International Society for Neurochemistry.)
Databáze: MEDLINE
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