| Autor: |
Cong NT; Faculty of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District No. 5, Ho Chi Minh City, Vietnam., Trang HTX; Faculty of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District No. 5, Ho Chi Minh City, Vietnam., Dung PD; Faculty of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District No. 5, Ho Chi Minh City, Vietnam., Phuong TH; Faculty of Chemistry, University of Sciences, Vietnam National University, 227 Nguyen Van Cu Street, District No. 5, Ho Chi Minh City 721337, Vietnam., Trung VQ; Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay District, Hanoi 100000, Vietnam., Dat ND; Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay District, Hanoi 100000, Vietnam., Anh DTT; Institute of Chemistry, Viet Nam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay District, Hanoi 100000, Vietnam., Tuyen NV; Institute of Chemistry, Viet Nam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay District, Hanoi 100000, Vietnam., Van Meervelt L; Department of Chemistry, KU Leuven, Celestijnenlaan 200F, PO box 2404, Leuven (Heverlee), B-3001, Belgium. |
| Abstrakt: |
Five 2-aroyl-5-bromobenzo[b]furan-3-ol compounds (two of which are new) and four new 2-aroyl-5-iodobenzo[b]furan-3-ol compounds were synthesized starting from salicylic acid. The compounds were characterized by mass spectrometry and 1 H NMR and 13 C NMR spectroscopy. Single-crystal X-ray diffraction studies of four compounds, namely, (5-bromo-3-hydroxybenzofuran-2-yl)(4-fluorophenyl)methanone, C 15 H 8 BrFO 3 , (5-bromo-3-hydroxybenzofuran-2-yl)(4-chlorophenyl)methanone, C 15 H 8 BrClO 3 , (5-bromo-3-hydroxybenzofuran-2-yl)(4-bromophenyl)methanone, C 15 H 8 Br 2 O 3 , and (4-bromophenyl)(3-hydroxy-5-iodobenzofuran-2-yl)methanone, C 15 H 8 BrIO 3 , were also carried out. The compounds were tested for their in vitro cytotoxicity on the four human cancer cell lines KB, Hep-G2, Lu-1 and MCF7. Six compounds show good inhibiting abilities on Hep-G2 cells, with IC 50 values of 1.39-8.03 µM. |
