| Autor: |
Pethő Z; Institute of Physiology II, University Münster, 48147 Münster, Germany., Najder K; Institute of Physiology II, University Münster, 48147 Münster, Germany., Carvalho T; Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 90126 Bari, Italy., McMorrow R; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, 3035 GD Rotterdam, The Netherlands., Todesca LM; Institute of Physiology II, University Münster, 48147 Münster, Germany., Rugi M; Institute of Physiology II, University Münster, 48147 Münster, Germany., Bulk E; Institute of Physiology II, University Münster, 48147 Münster, Germany., Chan A; Percuros B.V., 2333 CL Leiden, The Netherlands., Löwik CWGM; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, 3035 GD Rotterdam, The Netherlands.; Department of Oncology CHUV, UNIL and Ludwig Cancer Center, 1011 Lausanne, Switzerland., Reshkin SJ; Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 90126 Bari, Italy., Schwab A; Institute of Physiology II, University Münster, 48147 Münster, Germany. |
| Abstrakt: |
Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance. |
