Good or not good: Role of miR-18a in cancer biology.

Autor:	Kolenda T; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland.; Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warszawa, Poland., Guglas K; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warszawa, Poland., Kopczyńska M; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland.; Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland., Sobocińska J; Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland., Teresiak A; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland., Bliźniak R; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland., Lamperska K; Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland.
Jazyk:	angličtina
Zdroj:	Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2020 Sep-Oct; Vol. 25 (5), pp. 808-819. Date of Electronic Publication: 2020 Aug 12.
DOI:	10.1016/j.rpor.2020.07.006
Abstrakt:	miR-18a is a member of primary transcript called miR-17-92a (C13orf25 or MIR17HG) which also contains five other miRNAs: miR-17, miR-19a, miR-20a, miR-19b and miR-92a. This cluster as a whole shows specific characteristics, where miR-18a seems to be unique. In contrast to the other members, the expression of miR-18a is additionally controlled and probably functions as its own internal controller of the cluster. miR-18a regulates many genes involved in proliferation, cell cycle, apoptosis, response to different kinds of stress, autophagy and differentiation. The disturbances of miR-18a expression are observed in cancer as well as in different diseases or pathological states. The miR-17-92a cluster is commonly described as oncogenic and it is known as 'oncomiR-1', but this statement is a simplification because miR-18a can act both as an oncogene and a suppressor. In this review we summarize the current knowledge about miR-18a focusing on its regulation, role in cancer biology and utility as a potential biomarker. (© 2020 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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