First report of the lethal activity and synergism between deltamethrin, amitraz and piperonyl butoxide against susceptible and pyrethroid-resistant nymphs of Triatoma infestans.

Autor: Dadé MM; Universidad Nacional de Río Negro, Sede Alto Valle y Valle Medio, Escuela de Veterinaria y Producción Agroindustrial, Choele Choel, Rio Negro, 8360, Argentina; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 S/n, La Plata, 1900, Argentina; Cátedra de Farmacología Especial y Toxicología Especial, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata, 1900, Argentina. Electronic address: mdade@fcv.unlp.edu.ar., Daniele MR; Universidad Nacional de Río Negro, Sede Alto Valle y Valle Medio, Escuela de Veterinaria y Producción Agroindustrial, Choele Choel, Rio Negro, 8360, Argentina; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 S/n, La Plata, 1900, Argentina; Cátedra de Farmacología Especial y Toxicología Especial, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata, 1900, Argentina., Machicote M; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 S/n, La Plata, 1900, Argentina., Errecalde JO; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 S/n, La Plata, 1900, Argentina; Cátedra de Farmacología Especial y Toxicología Especial, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata, 1900, Argentina., Rodriguez-Vivas RI; Facultad de Medicina Veterinaria and Zootecnia, Universidad Autónoma de Yucatán, Carretera Mérida-Xmatkuil Km. 15.5, 97100, Mérida, Yucatán, Mexico.
Jazyk: angličtina
Zdroj: Experimental parasitology [Exp Parasitol] 2020 Nov; Vol. 218, pp. 107986. Date of Electronic Publication: 2020 Sep 01.
DOI: 10.1016/j.exppara.2020.107986
Abstrakt: In South America, Triatoma infestans (Hemiptera: Reduviidae) is the main vector of the parasite Trypanosoma cruzi, etiological agent of Chagas disease. The main strategy for vector control is to spray domestic structures with pyrethroids. Reports of populations of T. infestans with varying degrees of resistance to pyrethroids have made the search for alternative molecules for vector control necessary. In the first stage of this work we investigated the lethal activity of amitraz and deltamethrin against susceptible and pyrethroid-resistant nymphs of Triatoma infestans. Lethal dose at 50% (LD 50 ) of susceptible nymphs were compared with those recorded in pyrethroid-resistant nymphs and the resistance ratio (RR 50 ) was obtained. The RR 50 of deltamethrin was approximately 300. In the case of amitraz, we observed similar triatomicidal activity in the two nymph populations (RR 50 : 0.7). In a second stage of the work, we determined the synergistic effect of amitraz and piperonyl butoxide (PBO) on the lethal activity of deltamethrin. The strong synergistic effect of PBO on the lethal activity of deltamethrin in resistant nymphs produced a decrease in RR 50 to almost one third of the RR 50 reported in absence of the synergist. Amitraz plus PBO lethal activity was similarly increased in pyrethroid susceptible and resistant nymphs. Our data indicate that deltamethrin synergism by amitraz was higher against resistant than to susceptible nymphs (Synergist ratio (SR 50 ) of: 7.2- and 4.1-fold, respectively). In pyrethroid resistant nymphs, the highest level of synergism was obtained combining deltamethrin with amitraz and PBO (SR 50 : 26.7-fold). These results indicate that this combination could be considered an effective alternative for the control of T. infestans.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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