Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease?

Autor: Cruz Tapia RO; Department of Oral and Maxillofacial Pathology, Postgraduate and Research Division, Universidad Nacional Autónoma de México, Mexico City, Mexico., Peraza Labrador AJ; Department of Oral and Maxillofacial Pathology, Universidad El Bosque, Bogota, Colombia., Guimaraes DM; School of Dentistry, Centro Universitario do Estado do Para, Belem, Brazil., Matos Valdez LH; Faculty of Dentistry, Postgraduate Unit, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Jazyk: angličtina
Zdroj: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [Spec Care Dentist] 2020 Nov; Vol. 40 (6), pp. 555-560. Date of Electronic Publication: 2020 Sep 03.
DOI: 10.1111/scd.12520
Abstrakt: Background: Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS-CoV-2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection.
Aim: To describe the clinico-pathological oral mucosal lesions in four patients with confirmed SARS-CoV-2 infection.
Methods and Results: Four patients with COVID-19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica-like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID-19 was established.
Conclusion: Infection with SARS-CoV-2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long-term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID-19 disease.
(© 2020 Special Care Dentistry Association and Wiley Periodicals, Inc.)
Databáze: MEDLINE
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