Early Tranexamic Acid Administration After Traumatic Brain Injury Is Associated With Reduced Syndecan-1 and Angiopoietin-2 in Patients With Traumatic Intracranial Hemorrhage.

Autor:	Anderson TN; Traumatic Brain Injury Research Group (Ms Anderson), Department of Neurology (Dr Hinson), Department of Surgery (Mss Dewey and Rick and Drs Schreiber and Rowell), and Division of Trauma, Critical Care & Acute Care Surgery (Dr Schreiber), Oregon Health & Science University, Portland, Oregon; and Department of Surgery, Duke University Medical Center, Durham, North Carolina (Dr Rowell)., Hinson HE, Dewey EN, Rick EA, Schreiber MA, Rowell SE
Jazyk:	angličtina
Zdroj:	The Journal of head trauma rehabilitation [J Head Trauma Rehabil] 2020 Sep/Oct; Vol. 35 (5), pp. 317-323.
DOI:	10.1097/HTR.0000000000000619
Abstrakt:	Objective: To evaluate the effect of early tranexamic acid (TXA) administration on circulating markers of endotheliopathy. Setting: Twenty trauma centers in the United States and Canada. Participants: Patients with moderate-to-severe traumatic brain injury (TBI) (MS-TBI) and intracranial hemorrhage who were not in shock (systolic blood pressure ≥90 mm Hg). Design: TXA (2 g) or placebo administered prior to hospital arrival, less than 2 hours postinjury. Blood samples and head computed tomographic scan collected upon arrival. Plasma markers measured using Luminex analyte platform. Differences in median marker levels evaluated using t tests performed on log-transformed variables. Comparison groups were TXA versus placebo and less than 45 minutes versus 45 minutes or more from time of injury to treatment administration. Main Measures: Plasma levels of angiopoietin-1, angiopoietin-2, syndecan-1, thrombomodulin, thrombospondin-2, intercellular adhesion molecule 1, vascular adhesion molecule 1. Results: Demographics and Injury Severity Score were similar between the placebo (n = 129) and TXA (n = 158) groups. Levels of syndecan-1 were lower in the TXA group (median [interquartile range or IQR] = 254.6 pg/mL [200.7-322.0] vs 272.4 pg/mL [219.7-373.1], P = .05. Patients who received TXA less than 45 minutes postinjury had significantly lower levels of angiopoietin-2 (median [IQR] = 144.3 pg/mL [94.0-174.3] vs 154.6 pg/mL [110.4-209.8], P = .05). No differences were observed in remaining markers. Conclusions: TXA may inhibit early upregulation of syndecan-1 and angiopoietin-2 in patients with MS-TBI, suggesting attenuation of protease-mediated vascular glycocalyx breakdown. The findings of this exploratory analysis should be considered preliminary and require confirmation in future studies.
Databáze:	MEDLINE
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