Exportation of Monkeypox Virus From the African Continent.

Autor:	Mauldin MR; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., McCollum AM; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Nakazawa YJ; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Mandra A; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Whitehouse ER; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Davidson W; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Zhao H; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Gao J; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Li Y; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Doty J; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Yinka-Ogunleye A; Nigerian Centre for Disease Control, Abuja, Nigeria., Akinpelu A; Nigerian Centre for Disease Control, Abuja, Nigeria., Aruna O; International Health Regulations Strengthening Project, Global Public Health, Public Health England, London, United Kingdom., Naidoo D; World Health Organization Country Office, Abuja, Nigeria., Lewandowski K; Public Health England, London, United Kingdom., Afrough B; Public Health England, London, United Kingdom., Graham V; Public Health England, London, United Kingdom., Aarons E; Public Health England, London, United Kingdom., Hewson R; Public Health England, London, United Kingdom., Vipond R; Public Health England, London, United Kingdom., Dunning J; Public Health England, London, United Kingdom., Chand M; Public Health England, London, United Kingdom., Brown C; Public Health England, London, United Kingdom., Cohen-Gihon I; Department of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel., Erez N; Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel., Shifman O; Department of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel., Israeli O; Department of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel., Sharon M; Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel., Schwartz E; Institute of Tropical Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.; Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Beth-Din A; Department of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel., Zvi A; Department of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel., Mak TM; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore., Ng YK; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore., Cui L; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore., Lin RTP; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore., Olson VA; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Brooks T; Public Health England, London, United Kingdom., Paran N; Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel., Ihekweazu C; Nigerian Centre for Disease Control, Abuja, Nigeria., Reynolds MG; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Apr 19; Vol. 225 (8), pp. 1367-1376.
DOI:	10.1093/infdis/jiaa559
Abstrakt:	Background: The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa. Methods: Epidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak. Results: Isolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers. Conclusions: Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu