Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium.

Autor:	Wong YL; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore ephssm@nus.edu.sg.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; R&D Vision Sciences AMERA, Essilor International, Singapore., Zhu X; Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Yam JCS; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Hong Kong Eye Hospital, China, Hong Kong SAR.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China., Zhang K; Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore., Lanca C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Zhang X; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Han SY; Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., He W; Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China., Susvar P; Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India., Trivedi M; Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India., Yuan N; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Lambat S; Suraj Eye Institute, Nagpur, Maharashtra, India., Raman R; Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India., Song SJ; Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Wang YX; Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China., Bikbov MM; Ufa Eye Research Institute, Ufa, Bashkortostan, Russia., Nangia V; Suraj Eye Institute, Nagpur, Maharashtra, India., Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore., Lamoureux EL; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore., Lu Y; Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2021 Aug; Vol. 105 (8), pp. 1140-1148. Date of Electronic Publication: 2020 Sep 02.
DOI:	10.1136/bjophthalmol-2020-316648
Abstrakt:	Aims: To determine the prevalence and predictors of myopic macular degeneration (MMD) in a consortium of Asian studies. Methods: Individual-level data from 19 885 participants from four population-based studies, and 1379 highly myopic participants (defined as axial length (AL) >26.0 mm) from three clinic-based/school-based studies of the Asian Eye Epidemiology Consortium were pooled. MMD was graded from fundus photographs following the meta-analysis for pathologic myopia classification and defined as the presence of diffuse choroidal atrophy, patchy chorioretinal atrophy, macular atrophy, with or without 'plus' lesion (lacquer crack, choroidal neovascularisation or Fuchs' spot). Area under the curve (AUC) evaluation for predictors was performed for the population-based studies. Results: The prevalence of MMD was 0.4%, 0.5%, 1.5% and 5.2% among Asians in rural India, Beijing, Russia and Singapore, respectively. In the population-based studies, older age (per year; OR=1.13), female (OR=2.0), spherical equivalent (SE; per negative diopter; OR=1.7), longer AL (per mm; OR=3.1) and lower education (OR=1.9) were associated with MMD after multivariable adjustment (all p<0.001). Similarly, in the clinic-based/school-based studies, older age (OR=1.07; p<0.001), female (OR=2.1; p<0.001), longer AL (OR=2.1; p<0.001) and lower education (OR=1.7; p=0.005) were associated with MMD after multivariable adjustment. SE had the highest AUC of 0.92, followed by AL (AUC=0.87). The combination of SE, age, education and gender had a marginally higher AUC (0.94). Conclusion: In this pooled analysis of multiple Asian studies, older age, female, lower education, greater myopia severity and longer AL were risk factors of MMD, and myopic SE was the strongest single predictor of MMD. Competing Interests: Competing interests: YLW is an employee of Essilor International, Singapore. (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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