Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model.

Autor:	Zakko J; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio., Blum KM; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Biomedical Engineering, Ohio State University, Columbus, Ohio., Drews JD; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio., Wu YL; Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York., Hatoum H; Coulter Department of Biomedical Engineering, Georgia Tech, Atlanta, Georgia., Russell M; Oden Institute for Computational and Engineering Sciences, University of Texas at Austin, Austin, Texas., Gooden S; Coulter Department of Biomedical Engineering, Georgia Tech, Atlanta, Georgia., Heitkemper M; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Biomedical Engineering, Ohio State University, Columbus, Ohio., Conroy O; Oden Institute for Computational and Engineering Sciences, University of Texas at Austin, Austin, Texas., Kelly J; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Heart Center, Nationwide Children's Hospital, Columbus, Ohio., Carey S; Heart Center, Nationwide Children's Hospital, Columbus, Ohio., Sacks M; Oden Institute for Computational and Engineering Sciences, University of Texas at Austin, Austin, Texas., Texter K; Heart Center, Nationwide Children's Hospital, Columbus, Ohio., Ragsdale E; Department of OB/GYN-Maternal Fetal Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio., Strainic J; Department of Pediatric Cardiology, University Hospitals Rainbow Babies and Children's Hospital, School of Medicine, Case Western Reserve University, Cleveland, Ohio., Bocks M; University Hospitals Rainbow Babies and Children's Hospital, School of Medicine, Case Western Reserve University, Cleveland, Ohio., Wang Y; Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York., Dasi LP; Coulter Department of Biomedical Engineering, Georgia Tech, Atlanta, Georgia., Armstrong AK; Heart Center, Nationwide Children's Hospital, Columbus, Ohio., Breuer C; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio.
Jazyk:	angličtina
Zdroj:	JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Jul 29; Vol. 5 (8), pp. 815-828. Date of Electronic Publication: 2020 Jul 29 (Print Publication: 2020).
DOI:	10.1016/j.jacbts.2020.06.009
Abstrakt:	This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart. (© 2020 The Authors.)
Databáze:	MEDLINE
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