Some outcomes and a hypothetical mechanism of combined lead and benzo(a)pyrene intoxication, and its alleviation with a complex of bioprotectors.

Autor:	Minigalieva IA; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Shtin TN; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Makeyev OH; The Ural State Medical University, 620109 Ekaterinburg, Russia., Panov VG; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia.; The Institute of Industrial Ecology UB of RAS, 620990 Ekaterinburg, Russia., Privalova LI; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Gurvic VB; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Sutunkova MP; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Bushueva TV; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Sakhautdinova RR; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Klinova SV; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Solovyeva SN; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Chernyshov IN; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia., Shuman EA; The Ural State Medical University, 620109 Ekaterinburg, Russia., Korotkov AA; The Ural State Medical University, 620109 Ekaterinburg, Russia., Katsnelson BA; The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2020 Aug 12; Vol. 7, pp. 986-994. Date of Electronic Publication: 2020 Aug 12 (Print Publication: 2020).
DOI:	10.1016/j.toxrep.2020.08.004
Abstrakt:	Rats were exposed 3 times a week during 6 weeks to repeated intraperitoneal injections of lead acetate solution in water (Pb) and/or benzo(а)pyrene solution in petrolatum oil (B(а)P) in various dose ratios. Towards the end of the period, the animals developed a moderate subchronic intoxication having some features characteristic of lead effects. The type of combined toxicity estimated with the help of isoboles constructed by the Response Surface Methodology was found to be varied depending on a particular effect, its level, and dose ratio. However, Pb and B(a)P in combination often displayed an additive or even superadditive action. In the group exposed to this combination compared with the group of rats exposed to B(a)P alone, its concentration in the organism was increased while the concentration of some B(a)P oxidative metabolism products was reduced. Such inhibition of B(a)P biotransformation, assumingly associated with impaired heme and, thus, cytochrome P450 synthesis induced by lead intoxication, can serve as an explanation for certain enhancement of the genotoxic effect of B(a)P. This effect was not present in the same combined intoxication if a complex of antitoxic bioprotectors was being administered in the background. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2020 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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