Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: The Baependi Heart Study.

Autor:	de Oliveira CM; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Brazil.; Department of Integrative Medicine, Federal University of Paraná, Brazil.; Global CoCreation Lab, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA., Pavani J; Department of Statistics, Pontificia Universidad Católica de Chile, Chile., Liu C; Framingham Heart Study, Framingham, USA.; Department of Biostatistics, Boston University, USA., de Oliveira Alvim R; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Brazil.; Department of Physiological Sciences, Federal University of Amazonas, Brazil., Balcells M; Global CoCreation Lab, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA.; Bioengineering Department, Institut Quimic de Sarria, Ramon Llull Univ, Barcelona, Spain., Mourão-Junior CA; Department of Physiology, Federal University of Juiz de Fora, Brazil., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Brazil., da Costa Pereira A; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Brazil.
Jazyk:	angličtina
Zdroj:	Preventive medicine reports [Prev Med Rep] 2020 Aug 06; Vol. 20, pp. 101172. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2020).
DOI:	10.1016/j.pmedr.2020.101172
Abstrakt:	Considering that the incidence of type 2 diabetes mellitus (T2DM) has been increasing especially in developing countries and becoming a global public health problem, this study aims to evaluate the association between triglyceride glucose index (TyG) - which is a mathematical product of the fasting blood glucose and triglyceride levels - and incident T2DM in an adult sample in the Baependi Heart Study (BHS). The data were from the BHS cohort consisting of two periods: cycle 1 (2005-2006; n = 1712; 119 families) and cycle 2 (2010-2013; n = 3017; 127 families). A total of 1121 individuals (both sexes, 18-100 years) were selected if they were assessed in both cycles and not diagnosed with T2DM at baseline (cycle 1). Our findings showed that a participant's risk of developing T2DM increased almost 10 times for a one-unit increase in the TyG (odds ratio OR = 10.17, 95% CI, 7.51-13.93). The association when stratified by age was OR = 28.13 [95% CI, 14.03-56.41] for young adults, meaning that the risk of developing T2DM increased more than 28 times for a one-unit increase in the TyG. For the other groups, young middle-aged adults, old middle-aged adults, and seniors, we found OR = 4.84 [95% CI, 2.91-8.06], OR = 28.73 [95% CI, 10.63-77.65, and OR = 9.88 [95% CI, 3.16-30.90], respectively. A higher TyG implies a significant increase in the risk of developing T2DM, which could be an important screening tool to target early lifestyle intervention in Brazil. (© 2020 The Authors.)
Databáze:	MEDLINE
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