Modelling of the arteriovenous malformation embolization optimal scenario.

Autor:	Cherevko AA; Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Hydrodynamics Department, Novosibirsk State University, 630090 Novosibirsk, Russia., Gologush TS; Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Petrenko IA; Functional Analysis and its Applications Department, Vladimir State University, 600000 Vladimir, Russia., Ostapenko VV; Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Hydrodynamics Department, Novosibirsk State University, 630090 Novosibirsk, Russia., Panarin VA; Medical Center of Far Eastern Federal University, 690090 Vladivostok, Russia.
Jazyk:	angličtina
Zdroj:	Royal Society open science [R Soc Open Sci] 2020 Jul 22; Vol. 7 (7), pp. 191992. Date of Electronic Publication: 2020 Jul 22 (Print Publication: 2020).
DOI:	10.1098/rsos.191992
Abstrakt:	Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of AVM treatment methods is embolization-the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative AVM vessels rupture. In this paper, the optimal scenario of AVM embolization is studied from the safety and effectiveness of the procedure point of view. The co-movement of blood and embolic agent in the AVM body is modelled on the basis of a one-dimensional two-phase filtration model. Optimal control problem with phase constraints arising from medicine is formulated and numerically solved. In numerical analysis, the monotone modification of the CABARET scheme is used. Optimal embolization model is constructed on the basis of real patients' clinical data collected during neurosurgical operations. For the special case of embolic agent, input admissible and optimal embolization scenarios were calculated. Competing Interests: We declare we have no competing interest. (© 2020 The Authors.)
Databáze:	MEDLINE
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