Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk.

Autor: Demers-Mathieu V; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA. vdemers-m@medolac.com.; Department of Food Science, University of Massachusetts Amherst, Amherst, MA, USA. vdemers-m@medolac.com., Do DM; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA., Mathijssen GB; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA., Sela DA; Department of Food Science, University of Massachusetts Amherst, Amherst, MA, USA., Seppo A; Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Medical Center, Rochester, NY, USA., Järvinen KM; Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Medical Center, Rochester, NY, USA., Medo E; Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Apr; Vol. 41 (4), pp. 850-859. Date of Electronic Publication: 2020 Sep 01.
DOI: 10.1038/s41372-020-00805-w
Abstrakt: Objective: This study evaluated the presence and the levels of antibodies reactive to SARS-CoV-2 S1 and S2 subunits (S1 + S2), and nucleocapsid protein.
Study Design: The levels of SARS-CoV-2 S1 + S2- and nucleocapsid-reactive SIgM/IgM, IgG and SIgA/IgA were measured in human milk samples from 41 women during the COVID-19 pandemic (2020-HM) and from 16 women 2 years prior to the outbreak (2018-HM).
Results: SARS-CoV-2 S1 + S2-reactive SIgA/IgA, SIgM/IgM and IgG were detected in 97.6%, 68.3% and 58.5% in human milk whereas nucleocapsid-reactive antibodies were detected in 56.4%, 87.2% and 46.2%, respectively. S1 + S2-reactive IgG was higher in milk from women that had symptoms of viral respiratory infection(s) during the last year than in milk from women without symptom. S1 + S2- and nucleocapsid-reactive IgG were higher in the 2020-HM group compared to the 2018-HM group.
Conclusions: The presence of SARS-CoV-2-reactive antibodies in human milk could provide passive immunity to breastfed infants and protect them against COVID-19 diseases.
Databáze: MEDLINE
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