Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection.

Autor:	Diot A; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France., Dyon-Tafani V; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France., Bergot M; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France., Tasse J; BioFilm Control, 63360 Saint-Beauzire, France., Martins-Simões P; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France.; National Reference Center for Staphylococci, Hospices Civils de Lyon, 69004 Lyon, France., Josse J; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France.; Regional Reference Centre for Complex Bone and Joint Infection (CRIOAc Lyon), Hospices Civils de Lyon, 69004 Lyon, France., Valour F; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France.; Regional Reference Centre for Complex Bone and Joint Infection (CRIOAc Lyon), Hospices Civils de Lyon, 69004 Lyon, France.; Department of Infectious Diseases, Hospices Civils de Lyon, 69004 Lyon, France., Laurent F; CIRI-Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Lyon, 69007 Lyon, France.; National Reference Center for Staphylococci, Hospices Civils de Lyon, 69004 Lyon, France.; Regional Reference Centre for Complex Bone and Joint Infection (CRIOAc Lyon), Hospices Civils de Lyon, 69004 Lyon, France.; Department of Bacteriology, Institute for Infectious Agents, Hospices Civils de Lyon, 69004 Lyon, France.
Jazyk:	angličtina
Zdroj:	International journal of molecular sciences [Int J Mol Sci] 2020 Aug 28; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 28.
DOI:	10.3390/ijms21176245
Abstrakt:	Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus . It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated S. argenteus strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in comparison with two other strains of S. argenteus and two S. aureus isolates. It appeared that this S. argenteus PJI strain combined biofilm formation, osteoblast invasion and intracellular persistence abilities together with genes potentially involved in the escape of the host immune defenses, which might explain the chronicization of the infection.
Databáze:	MEDLINE
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