International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium.

Autor:	Brat GA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Weber GM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Gehlenborg N; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Avillach P; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Palmer NP; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Chiovato L; IRCCS ICS Maugeri, Pavia, Italy.; Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy., Cimino J; UAB Informatics Institute, Birmingham, AL USA., Waitman LR; Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, KS USA., Omenn GS; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI USA., Malovini A; IRCCS ICS Maugeri, Pavia, Italy., Moore JH; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA.; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA., Beaulieu-Jones BK; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Tibollo V; IRCCS ICS Maugeri, Pavia, Italy., Murphy SN; Department of Neurology, Massachusetts General Hospital, Boston, MA USA., Yi SL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Keller MS; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Bellazzi R; IRCCS ICS Maugeri, Pavia, Italy.; Department of Electrical Computer and Biomedical Engineering, University of Pavia, Pavia, Italy., Hanauer DA; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI USA., Serret-Larmande A; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Gutierrez-Sacristan A; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Holmes JJ; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI USA., Bell DS; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA USA., Mandl KD; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA USA., Follett RW; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA USA., Klann JG; Department of Medicine, Massachusetts General Hospital, Boston, MA USA., Murad DA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA USA., Scudeller L; Scientific Direction, IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy., Bucalo M; BIOMERIS (BIOMedical Research Informatics Solutions), Pavia, Italy., Kirchoff K; Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC USA., Craig J; Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC USA., Obeid J; Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC USA., Jouhet V; Bordeaux University Hospital, Bordeaux, France., Griffier R; Bordeaux University Hospital, Bordeaux, France., Cossin S; Bordeaux University Hospital, Bordeaux, France., Moal B; Bordeaux University Hospital, Bordeaux, France., Patel LP; Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, KS USA., Bellasi A; UOC Ricerca, Innovazione e Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy., Prokosch HU; Department of Medical Informatics, University of Erlangen-Nürnberg, Erlangen, Germany., Kraska D; Center for Medical Information and Communication Technology, University Hospital Erlangen, Erlangen, Germany., Sliz P; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA USA., Tan ALM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Ngiam KY; National University Health Systems, Singapore, Singapore., Zambelli A; Department of Oncology, ASST Papa Giovanni XXIII, Bergamo, Italy., Mowery DL; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI USA., Schiver E; Penn Medicine, Data Analytics Center, Philadelphia, PA USA., Devkota B; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA USA., Bradford RL; North Carolina Translational and Clinical Sciences (NC TraCS) Institute, UNC Chapel Hill, Chapel Hill, NC USA., Daniar M; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA USA., Daniel C; WIND Department APHP Greater Paris University Hospital, Paris, France., Benoit V; WIND Department APHP Greater Paris University Hospital, Paris, France., Bey R; WIND Department APHP Greater Paris University Hospital, Paris, France., Paris N; WIND Department APHP Greater Paris University Hospital, Paris, France., Serre P; WIND Department APHP Greater Paris University Hospital, Paris, France., Orlova N; WIND Department APHP Greater Paris University Hospital, Paris, France., Dubiel J; WIND Department APHP Greater Paris University Hospital, Paris, France., Hilka M; WIND Department APHP Greater Paris University Hospital, Paris, France., Jannot AS; Department of Biomedical Informatics, HEGP, APHP Greater Paris University Hospital, Paris, France., Breant S; WIND Department APHP Greater Paris University Hospital, Paris, France., Leblanc J; Clinical Research Unit, Saint Antoine Hospital, APHP Greater Paris University Hospital, Paris, France., Griffon N; WIND Department APHP Greater Paris University Hospital, Paris, France., Burgun A; Department of Biomedical Informatics, HEGP, APHP Greater Paris University Hospital, Paris, France., Bernaux M; Strategy and Transformation Department, APHP Greater Paris University Hospital, Paris, France., Sandrin A; WIND Department APHP Greater Paris University Hospital, Paris, France., Salamanca E; WIND Department APHP Greater Paris University Hospital, Paris, France., Cormont S; WIND Department APHP Greater Paris University Hospital, Paris, France., Ganslandt T; Heinrich-Lanz-Center for Digital Health, University Medicine Mannheim, Heidelberg University, Mannheim, Germany., Gradinger T; Heinrich-Lanz-Center for Digital Health, University Medicine Mannheim, Heidelberg University, Mannheim, Germany., Champ J; INRIA Sophia-Antipolis-ZENITH Team, LIRMM, Montpellier, France., Boeker M; Institute of Medical Biometry and Statistics, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany., Martel P; Clinical Research Unit, Paris Saclay, APHP Greater Paris University Hospital, Paris, France., Esteve L; SED/SIERRA, Inria Centre de Paris, Paris, France., Gramfort A; Université Paris-Saclay, Inria, CEA, Paris, France., Grisel O; Université Paris-Saclay, Inria, CEA, Paris, France., Leprovost D; Clevy.io, Paris, France., Moreau T; Université Paris-Saclay, Inria, CEA, Paris, France., Varoquaux G; Université Paris-Saclay, Inria, CEA, Paris, France., Vie JJ; SequeL, Inria Lille, Paris, France., Wassermann D; Université Paris-Saclay, Inria, CEA, Paris, France., Mensch A; ENS, PSL University, Paris, France., Caucheteux C; Université Paris-Saclay, Inria, CEA, Paris, France., Haverkamp C; Institute of Digitalization in Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, Germany., Lemaitre G; Université Paris-Saclay, Inria, CEA, Paris, France., Bosari S; IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy., Krantz ID; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA USA., South A; Brenner Children's Hospital, Wake Forest School of Medicine, Winston-Salem, NC USA., Cai T; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA., Kohane IS; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA.
Jazyk:	angličtina
Zdroj:	NPJ digital medicine [NPJ Digit Med] 2020 Aug 19; Vol. 3, pp. 109. Date of Electronic Publication: 2020 Aug 19 (Print Publication: 2020).
DOI:	10.1038/s41746-020-00308-0
Abstrakt:	We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions. Competing Interests: Competing interestsR.B. and A.M. are shareholders of Biomeris s.r.l. (© The Author(s) 2020.)
Databáze:	MEDLINE
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