| Autor: |
Kaur K; Department of Chemical Engineering, University of Utah., Mohammadpour R; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah., Jaramillo IC; Department of Chemical Engineering, University of Utah., Ghandehari H; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah.; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah.; Department of Bioengineering, University of Utah., Reilly C; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah.; Department of Pharmacology and Toxicology, University of Utah., Paine R; Department of Pulmonary Medicine, University of Utah., Kelly KE; Department of Chemical Engineering, University of Utah.; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah. |
| Abstrakt: |
Researchers studying the biological effects of combustion particles typically rely on suspending particles in de-ionized (DI) water, buffer, and/or media prior to in vitro or in vivo experiments. However, the hydrophobic nature of combustion particles makes it difficult to obtain well-suspended, evenly dispersed mixtures, which also makes it difficult to obtain equivalent dosing and endpoint comparisons. This study explored the use of a quartz crystal microbalance (QCM) to measure the mass concentration of combustion particle suspensions. It compared the QCM mass concentration to that estimated by placing a known mass of combustion particles in DI water. It also evaluated the effect of drop volume and combustion particle type on QCM measurements. The results showed that QCM is a promising direct method for measuring suspended combustion particle mass concentrations, and it is particularly effective for quantifying concentrations of difficult-to-suspend particles and for combustion particles placed in polystyrene containers, which can lead to substantial particle losses. |
Full Text from ScienceDirect