Fine Spike Timing in Hippocampal-Prefrontal Ensembles Predicts Poor Encoding and Underlies Behavioral Performance in Healthy and Malformed Brains.

Autor:	Hernan AE; Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington VT 05401, USA., Mahoney JM; Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington VT 05401, USA.; Department of Computer Science, University of Vermont, Burlington VT 05401, USA., Curry W; Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington VT 05401, USA., Mawe S; Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington VT 05401, USA., Scott RC; Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington VT 05401, USA.; Neurosciences Unit University College London, Institute of Child Health, London WC1N 1EH, UK.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2021 Jan 01; Vol. 31 (1), pp. 147-158.
DOI:	10.1093/cercor/bhaa216
Abstrakt:	Spatial working memory (SWM) is a central cognitive process during which the hippocampus and prefrontal cortex (PFC) encode and maintain spatial information for subsequent decision-making. This occurs in the context of ongoing computations relating to spatial position, recall of long-term memory, attention, among many others. To establish how intermittently presented information is integrated with ongoing computations we recorded single units, simultaneously in hippocampus and PFC, in control rats and those with a brain malformation during performance of an SWM task. Neurons that encode intermittent task parameters are also well modulated in time and incorporated into a functional network across regions. Neurons from animals with cortical malformation are poorly modulated in time, less likely to encode task parameters, and less likely to be integrated into a functional network. Our results implicate a model in which ongoing oscillatory coordination among neurons in the hippocampal-PFC network describes a functional network that is poised to receive sensory inputs that are then integrated and multiplexed as working memory. The background temporal modulation is systematically altered in disease, but the relationship between these dynamics and behaviorally relevant firing is maintained, thereby providing potential targets for stimulation-based therapies. (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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