Fat density is a novel prognostic marker in patients with esophageal cancer.

Autor: Anciaux M; Digestive Oncology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Van Gossum A; Medico-Surgical Department of Gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium., Wenglinski C; Digestive Oncology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Ameye L; Data Centre, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Guiot T; Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Flamen P; Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Demetter P; Department of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium., Deleporte A; Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Sclafani F; Digestive Oncology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Donckier V; Department of Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Hendlisz A; Digestive Oncology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: alain.hendlisz@bordet.be., Vandeputte C; Digestive Oncology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2020 Oct; Vol. 39, pp. 124-130. Date of Electronic Publication: 2020 Aug 11.
DOI: 10.1016/j.clnesp.2020.07.007
Abstrakt: Background & Aims: While long-term obesity is a well-known risk factor for esophageal adenocarcinoma (ADC), recent weight loss represents a significant concern in esophageal cancer (EC), in relation with dysphagia and disease aggressiveness. These phenomenons may diversely impact the adipose tissue density, suggested in other cancer settings as an important prognostic biomarker. The analysis of body mass composition (BMC) parameters, including adipose tissue attenuation is studied here in a population of EC operated with curative intent.
Methods: BMC was retrospectively evaluated on Computed-Tomography (CT)-scan images from fluorodeoxyglucose (FDG)-positron-emitting (PET)/CT scans performed as a diagnostic procedure in a cohort of 145 EC patients operated with curative intent The mean subcutaneous (SFD) and visceral fat (VFD) density along with the index (area/height 2 ) (SF index (SFI), VF index (VFI)) were assessed on two adjacent slides at the third lumbar vertebra level by two independent investigators. Overall survival (OS) was calculated from the date of the baseline FDG-PET/CT scan.
Results: Inter-observer correlations are excellent for all BMC parameters (r = 0.94-0.99). As expected, weight loss is associated with worse outcome. We show that low SFD (HR 0.5 (95% CI: 0.3-0.7), p < 0.001) and low VFD (HR 0.6 (95% CI: 0.4-0.9), p = 0.04) at diagnosis are associated with better OS. In contrast, body mass index (BMI) fails to show any relevance in predicting survival.
Conclusions: Adipose tissue density is an important prognostic factor in EC.
(Copyright © 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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