Sustained attention in schoolchildren with type-1 diabetes. A quantitative EEG study.

Autor: Gallardo-Moreno GB; Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180 Col. Arcos Vallarta, 44130 Guadalajara, Jalisco, Mexico. Electronic address: geisa.gallardo@academicos.udg.mx., González-Garrido AA; Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180 Col. Arcos Vallarta, 44130 Guadalajara, Jalisco, Mexico; O.P.D. Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico., Villaseñor-Cabrera T; O.P.D. Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México, Sierra Mojada 950, Puerta 1, Edificio N Planta Baja, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico., Alvarado-Rodríguez FJ; Departamento de Ciencias Computacionales, CUCEI, Universidad de Guadalajara, Blvd. Gral. Marcelino García Barragán 1421, Col. Olímpica, 44430 Guadalajara, Jalisco, Mexico., Ruiz-Stovel VD; Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180 Col. Arcos Vallarta, 44130 Guadalajara, Jalisco, Mexico., Jiménez-Maldonado ME; O.P.D. Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México, Sierra Mojada 950, Puerta 1, Edificio N Planta Baja, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico., Contreras-Piña N; Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180 Col. Arcos Vallarta, 44130 Guadalajara, Jalisco, Mexico., Gómez-Velázquez FR; Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180 Col. Arcos Vallarta, 44130 Guadalajara, Jalisco, Mexico.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2020 Oct; Vol. 131 (10), pp. 2469-2478. Date of Electronic Publication: 2020 Aug 10.
DOI: 10.1016/j.clinph.2020.07.013
Abstrakt: Objective: Type-1 diabetes (T1D) is a disruptive metabolic disease that has an impact on neurodevelopment through its effects on the structure and function of the brain. One of the cognitive domains affected by T1D is sustained attention. The aim of this study was to analyze this process in children with T1D and compare their results to those of healthy controls.
Methods: Seventeen T1D children attending regular primary school and a similar group of healthy children matched by gender, age, handedness, and educational level were evaluated while identifying happy faces in a Go-NoGo task presented visually with simultaneous electrophysiological recording.
Results: Behavioral performance in the two groups was similar but, the T1D children showed greater prefrontal and frontoparietal spectral power in the theta and alpha bands, compared to controls. Distinct patterns of theta lateralization between groups were also observed, with a negative correlation between frontal power magnitudes in delta and theta and glycated hemoglobin levels.
Conclusions: These results seem to reflect the early deleterious effects of T1D on neurodevelopment, which affects mainly attention allocation processes and the neurofunctional substrates that underlie them.
Significance: This phenomenon emphasizes the need for studies on neural-specific targets in which T1D affects neurodevelopment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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