Dexamethasone and Training-Induced Cardiac Remodeling Improve Cardiac Function and Arterial Pressure in Spontaneously Hypertensive Rats.

Autor:	Duchatsch F; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos/SP, Brazil., Tardelli LP; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos/SP, Brazil., Herrera NA; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos/SP, Brazil., Ruiz TFR; Department of Biological Sciences, School of Sciences, 28108São Paulo State University (Unesp), Bauru/SP, Brazil., Vicentini CA; Department of Biological Sciences, School of Sciences, 28108São Paulo State University (Unesp), Bauru/SP, Brazil., Okoshi K; Department of Internal Medicine, Botucatu Medical School, 28108São Paulo State University (Unesp), Botucatu/SP, Brazil., Santos CF; Department of Biological Sciences, Bauru School of Dentistry, 28133University of São Paulo (Usp), Bauru/SP, Brazil., Amaral SL; Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos/SP, Brazil.; Department of Physical Education, School of Sciences, 28108São Paulo State University (Unesp), Bauru/SP, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular pharmacology and therapeutics [J Cardiovasc Pharmacol Ther] 2021 Mar; Vol. 26 (2), pp. 189-199. Date of Electronic Publication: 2020 Aug 28.
DOI:	10.1177/1074248420953271
Abstrakt:	Introduction: Dexamethasone (DEX)-induced hypertension and cardiac remodeling are still unclear, especially in spontaneously hypertensive rats (SHR). On the other side, exercise training is a good strategy to control hypertension. Therefore, this study investigated the effects of DEX treatment and physical training on arterial pressure and cardiac remodeling in SHR. Material and Methods: SHR underwent treadmill training (5 days/week, 1h/session, at 50-60% of maximal capacity, 0% degree, 75 days) and received low-dose of DEX (50µg/kg, s.c. ) during the last 15 days. Sedentary Wistar rats (W) were used as control. Echocardiography and artery catheterization were performed for cardiac remodeling and function, arterial pressure and autonomic nervous system analyses. In addition, left ventricle (LV) capillary density, myocyte diameter and collagen deposition area were analyzed using specific histological staining. Results: Low-dose of DEX treatment did not exacerbate arterial pressure of SHR and trained groups had lower values, regardless of DEX. DEX and training decreased relative left ventricle wall thickness (RWT) and determined LV angiogenesis (+19%) and lower collagen deposition area (-22%). In addition, it determined increased left ventricular diastolic diameter. These changes were followed by improvements on systolic and diastolic function, since it was observed increased posterior wall shortening velocity (PWSV) and reduced isovolumetric relaxation time (IVRT). Conclusion: In conclusion, this study is unique to indicate that low-dose of DEX treatment does not exacerbate arterial pressure in SHR and, when associated with training, it improves LV systolic and diastolic function, which may be due to LV angiogenesis and reduction of wall collagen deposition area.
Databáze:	MEDLINE
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