Regen med therapeutic opportunities for fighting COVID-19.

Autor: Atala A; Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA., Henn A; Biospherix, Lacona, New York, USA., Lundberg M; National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, USA., Ahsan T; RoosterBio, Frederick, Maryland, USA., Greenberg J; Organabio, Miami, Florida, USA., Krukin J; Orbital Transports, Chicago, Illinois, USA., Lynum S; PHC Group, Livingston, New Jersey, USA., Lutz C; Jackson Labs, Mount Desert Island, Maine, USA., Cetrulo K; International Perinatal Stem Cell Society, Inc., Westport, Connecticut, USA., Albanna M; Humabiologics, Inc., Phoenix, Arizona, USA., Pereira T; Allevi, Philadelphia, Pennsylvania, USA., Eaker S; Cytiva, Marlborough, Massachusetts, USA., Hunsberger J; Regenerative Medicine Manufacturing Society, Winston-Salem, North Carolina, USA.
Jazyk: angličtina
Zdroj: Stem cells translational medicine [Stem Cells Transl Med] 2021 Jan; Vol. 10 (1), pp. 5-13. Date of Electronic Publication: 2020 Aug 27.
DOI: 10.1002/sctm.20-0245
Abstrakt: This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19. This article addresses why SARS-CoV-2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID-19. We describe animal models that depict the mechanism of action for COVID-19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at-risk patients. This article critically evaluates some of the promising regenerative medicine-based therapies for treating COVID-19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.
(© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.)
Databáze: MEDLINE
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