Comparison of Current Optical Coherence Tomography Angiography Methods in Imaging Retinal Hemangioblastomas.

Autor:	Reich M; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Glatz A; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Boehringer D; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Evers C; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Daniel M; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bucher F; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ludwig F; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Nuessle S; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lagrèze WA; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Maloca PM; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.; Moorfields Eye Hospital NHS Foundation Trust, London, UK., Lange C; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Reinhard T; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Agostini H; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lang SJ; Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2020 Jul 08; Vol. 9 (8), pp. 12. Date of Electronic Publication: 2020 Jul 08 (Print Publication: 2020).
DOI:	10.1167/tvst.9.8.12
Abstrakt:	Purpose: To compare spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) for imaging retinal capillary hemangioblastomas (RCHs) in von Hippel-Lindau disease (VHLD). Methods: Prospective single-center cross-sectional study. Tumor size (TS) of perfused RCHs was assessed clinically in relation to the optic disc size. For both technologies, SD-OCTA and SS-OCTA, corresponding images with a scan size of 3 × 3 mm ² and 6 × 6 mm ² , respectively, were overlaid according to the set of marker positions to determine the TS. Results: From 200 patients with VHLD, 48 patients showed 84 RCHs. SD-OCTA images of 39 RCHs (46.4%) and SS-OCTA images of 48 RCHs (57.2%) were suitable for analysis. The average in OCTA-measured TS of 1.60 ± 2.58 mm ² (range, 0.01-10.43) was congruent to the clinically assessed TS in 81.3% of cases ( r = 0.86, P < 0.0001). TS measured in SD-OCTA compared to SS-OCTA showed similar values and a high correlation (all P < 0.0001). Nevertheless, despite the similarities, a slight trend in SS-OCTA was observed whereby with increasing TS, an elevated TS was detected compared to SD-OCTA (3 × 3-mm ² scans: mean difference of 0.03 ± 0.04 mm ² , 6 × 6-mm ² scans: 0.08 ± 0.19 mm ² ). However, within the same imaging technology method, TS values almost did not differ (SD-OCTA: mean difference of 0.01 ± 0.02 mm ² , SS-OCTA: 0.001 ± 0.01 mm ² ). Conclusions: OCTA may serve as an additional tool for diagnosis and monitoring of RCHs. Nevertheless, due to the differences between the technologies, the values cannot be used interchangeably. Translational Relevance: SD-OCTA and SS-OCTA are suitable to detect and monitor RCHs and provide a more detailed assessment about the TS than this is clinically possible. Competing Interests: Disclosure: M. Reich, None; A. Glatz, None; D. Boehringer, None; C. Evers, None; M. Daniel, None; F. Bucher, None; F. Ludwig, None; S. Nuessle, None; W.A. Lagrèze, None; P.M. Maloca, None; C. Lange, None; T. Reinhard, None; H. Agostini, None; S.J. Lang, None (Copyright 2020 The Authors.)
Databáze:	MEDLINE
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