Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases.

Autor:	Wissler Gerdes EO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Weigand BM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Burns TC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States. Electronic address: kirkland.james@mayo.edu.
Jazyk:	angličtina
Zdroj:	International review of neurobiology [Int Rev Neurobiol] 2020; Vol. 155, pp. 203-234. Date of Electronic Publication: 2020 Aug 11.
DOI:	10.1016/bs.irn.2020.03.019
Abstrakt:	Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological sites of many age-related chronic diseases. These cells are resistant to apoptosis and can cause local and systemic dysfunction. Decreasing senescent cell abundance using senolytic drugs, agents that selectively target these cells, alleviates neurodegenerative diseases in preclinical models. In this review, we consider roles of senescent cells in neurodegenerative diseases and potential implications of senolytic agents as an innovative treatment. Competing Interests: Competing financial interests J.L.K., T.T., and Y.Z. have a financial interest related to this research. Patents on senolytic drugs are held by Mayo Clinic. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic Conflict of Interest policies. No conflicts of interest, financial or otherwise, are declared by E.O.W.G., B.M.W., U.T., or T.C.B. (© 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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