Urinary cytology: a potential tool for differential diagnosis of acute kidney injury in patients with nephrotic syndrome.

Autor:	de Melo CVB; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Rua Waldemar Falcão 121, Candeal, Salvador, BA, CEP 40296-710, Brazil., Tavares MB; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Rua Waldemar Falcão 121, Candeal, Salvador, BA, CEP 40296-710, Brazil., Fernandes PN; Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil., Dos Santos Silva CA; Medicine Department, Federal University of Bahia, Salvador, BA, Brazil., Couto RD; Pharmaceutic Department, Federal University of Bahia, Salvador, BA, Brazil., Oliveira MB; Nephrology Department, Ana Nery Hospital, Salvador, BA, Brazil., Dos-Santos WLC; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Rua Waldemar Falcão 121, Candeal, Salvador, BA, CEP 40296-710, Brazil. wluis@bahia.fiocruz.br.
Jazyk:	angličtina
Zdroj:	BMC research notes [BMC Res Notes] 2020 Aug 27; Vol. 13 (1), pp. 401. Date of Electronic Publication: 2020 Aug 27.
DOI:	10.1186/s13104-020-05244-6
Abstrakt:	Objective: Acute tubular necrosis (ATN) is a frequent cause of acute kidney injury (AKI). In patients with nephrotic syndrome (NS), AKI demands the differential diagnosis between ATN and rapidly progressive glomerulonephritis. In some cases, conclusive diagnosis is possible only by kidney biopsy. We aimed to study the potential use of urine cytology in the differential diagnosis between ATN and proliferative glomerular lesion in patients with NS. Results: Cell size analysis showed a higher proportion of small cells and a lower proportion of large cells in the urine of patients with AKI. Cells phenotypes were easily defined using cytological preparations. Leukocytes were found to be a primary classifier of NS groups, with higher number in patients with AKI and patients with proliferative glomerular lesions. Although renal biopsy is still required for confirmative diagnosis, our data suggests that urinary cytology can be readily performed and support the differential diagnosis between proliferative glomerular lesion and ATN in patients with NS and AKI.
Databáze:	MEDLINE
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