[Consequences of Gout and Hyperuricemia].

Autor:	Dehlin M, Kapetanovic M, Svärd A; med dr, överläkare, Falu lasarett; Centrum för klinisk forskning Dalarna, Uppsala universitet; institutionen för medicin, Sahlgrenska akademin, Göteborgs universitet., Bengtsson Boström K; adjungerad professor, distriktsläkare, institutionen för medicin, Sahlgrenska akademin, Göteborgs universitet., Wändell P, Sigurdardottir V; specialistläkare, Falu lasarett; Centrum för klinisk forskning Dalarna, Uppsala universitet; institutionen för medicin, Sahlgrenska akademin, Göteborgs universitet., Forsblad d'Elia H, Jacobsson L
Jazyk:	švédština
Zdroj:	Lakartidningen [Lakartidningen] 2020 Aug 25; Vol. 117. Date of Electronic Publication: 2020 Aug 25.
Abstrakt:	Hyperuricemia (HU) and gout are strongly associated with CVD, associations that are most likely due to shared etiologies rather than causality. HU is for example causally related to the metabolic syndrome and in particular to obesity. Gout and HU can both be caused by and lead to decreased kidney function. On the other hand, there are observational data suggesting that HU may protect against neurodegenerative diseases such as Alzheimer and Parkinson's disease. Ongoing RCTs with urate and urate lowering therapy (ULT) will help to resolve some of these controversies. Nevertheless, gout is a "curable disease" by ULT, a treatment which in adequate doses may also have positive effect on several associated co-morbidities.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu