Adult brain activation in response to pain is changed by neonatal painful stimulation according to sex: A manganese-enhanced MRI study.

Autor: Malheiros JM; Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil., Andreeta MB; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil., Polli RS; Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, Brazil., Paiva FF; Centro de Imagens e Espectroscopia in vivo por Ressonância Magnética (CIERMag), Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil., Tannús A; Centro de Imagens e Espectroscopia in vivo por Ressonância Magnética (CIERMag), Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil., Guinsburg R; Disciplina de Pediatria Neonatal, Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil., Covolan L; Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2021 Jan; Vol. 53 (2), pp. 571-587. Date of Electronic Publication: 2020 Sep 09.
DOI: 10.1111/ejn.14948
Abstrakt: Although it is known that nociceptive stimulation in the first postnatal week in rats is useful to model preterm pain, resulting in activation of specific brain areas, as assessed in vivo using manganese-enhanced magnetic resonance imaging (MEMRI), little is known about its long-term effects and sex specificity. Here we aimed to investigate whether inflammatory pain induced in male and female adult rats modify the pattern of brain activation between animals subjected or not to neonatal pain. For this, Complete Freund's adjuvant (CFA) was injected into the left hind paw of rat pups on postnatal day 1 (P1) or P8 to induce inflammatory response. During adulthood, CFA-treated and control animals were injected with CFA 1 hr prior MRI. MEMRI has the ability to enhance the contrast of selective brain structures in response to a specific stimulus, as the pain. MEMRI responses were consistent with activation of nociceptive pathways and these responses were reduced in animals treated with CFA on P1, but increased in animals treated on P8, mainly in the female group. In agreement, P8 female group showed exacerbated responses in the thermal nociceptive test. Using MEMRI, we conclude that the natural ability of adult rats to recognize and react to pain exposition is modified by neonatal painful exposition, mainly among females.
(© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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