"Reactance inversion" at low frequencies in a child undergoing treatment of a cystic fibrosis exacerbation.

Autor: Allen JL; Division of Pulmonary Medicine The Children's Hospital of Philadelphia Philadelphia PA USA., Ren CL; Riley Hospital for Children Indiana University School of Medicine Indianapolis IN USA., McDonough J; Division of Pulmonary Medicine The Children's Hospital of Philadelphia Philadelphia PA USA., Clem CC; Riley Hospital for Children Indiana University School of Medicine Indianapolis IN USA.
Jazyk: angličtina
Zdroj: Pediatric investigation [Pediatr Investig] 2019 Dec 21; Vol. 3 (4), pp. 257-260. Date of Electronic Publication: 2019 Dec 21 (Print Publication: 2019).
DOI: 10.1002/ped4.12169
Abstrakt: Introduction: Impulse oscillometry (IOS) employs high frequency sinusoidal or impulse pressure and flow waveforms to interrogate the mechanical properties of the respiratory system. It has special applications to preschool and younger children who may have difficulty performing the repetitive forced expiratory maneuvers required for spirometry.
Case Presentation: We present a case illustrating improvements of respiratory system mechanics measured by IOS in a 6-year-old child with cystic fibrosis (CF) who demonstrated clinical and radiological improvement after a course of therapy with hospitalization and intravenous antibiotics, and initiation of a cystic fibrosis transmembrane regulator (CFTR) protein corrector/potentiator agent. We also report a new finding: observed lower than expected reactance at low compared to high frequencies ("reactance inversion").
Conclusion: Reactance inversion may reflect parallel pathway inhomogeneities in resistance and elastance or intrabreath airway inertance changes in young children with CF. Further study is needed in children with airway obstruction due to asthma, cystic fibrosis, and chronic lung disease of infancy to demonstrate the prevalence of this finding and whether it is specific to a measurement device.
Competing Interests: The authors declare no conflicts of interest.
(© 2019 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development.)
Databáze: MEDLINE
Externí odkaz: