Study of the Link Between Neuronal Death, Glial Response, and MAPK Pathway in Old Parkinsonian Mice.

Autor:	Gil-Martinez AL; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain.; School for Mental Health and Neuroscience (MHeNs), Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands., Cuenca-Bermejo L; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain., Gallo-Soljancic P; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain., Sanchez-Rodrigo C; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain., Izura V; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain., Steinbusch HWM; School for Mental Health and Neuroscience (MHeNs), Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands., Fernandez-Villalba E; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain., Herrero MT; Clinical and Experimental Neuroscience Group (NiCE), Institute for Aging Research, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), University of Murcia, Murcia, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2020 Jul 29; Vol. 12, pp. 214. Date of Electronic Publication: 2020 Jul 29 (Print Publication: 2020).
DOI:	10.3389/fnagi.2020.00214
Abstrakt:	Background : Parkinson's disease (PD) is described as an age-related neurodegenerative disorder. However, the vast majority of research is carried out using experimental models of young animals lacking the implications of the decline processes associated with aging. It has been suggested that several molecular pathways are involved in the perpetuation of the degeneration and the neuroinflammation in PD. Among others, mitogen-activated protein kinases (MAPKs) have been highly implicated in the development of PD, and regulating components of their activity are indicated as promising therapeutic targets. Methods : To further define how MAPKs expression is related to the glial response and neuronal cell death, Parkinsonism was induced under an acute regimen in old mice. Moreover, the sacrifice was carried out at different time points (4, 8, 24, and 48 h) after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) injections to describe the early dynamic changes over time produced by the intoxication. Results : The results revealed that neuronal death increases as glial response increases in the nigrostriatal pathway. It was observed that both processes increase from 4 h in the ventral mesencephalon (VM), and neuronal death becomes significant at 48 h. In the striatum, they were significantly increased from 48 h after the MPTP administration compared with that in the control mice. Moreover, the p-ERK levels decrease, while phospho-p38 expression increases specifically in the striatum at 48 h after MPTP intoxication. Conclusions : The importance of these data lies in the possibility of elucidating the underlying mechanisms of neurodegenerative processes under aging conditions to provide knowledge for the search of solutions that slow down the progression of PD. (Copyright © 2020 Gil-Martinez, Cuenca-Bermejo, Gallo-Soljancic, Sanchez-Rodrigo, Izura, Steinbusch, Fernandez-Villalba and Herrero.)
Databáze:	MEDLINE
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