| Autor: |
de Moraes Filho AV; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil. aroldodemoraes@gmail.com., Manso JAX; Replicon Research Center, Master's Program in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil., Martins WE; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil., Marinho NA; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil., de Oliveira Santos M; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil., Perim Neto J; Replicon Research Center, Master's Program in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil., Duarte SSM; Replicon Research Center, Master's Program in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil., da Cruz AD; Replicon Research Center, Master's Program in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil., da Silva CC; Replicon Research Center, Master's Program in Genetics, School of Agrarian and Biological Sciences, Pontifical Catholic University of Goiás, Goiânia, Goiás, Brazil., Barbosa MS; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil., de Jesus Pires D; Goiás State University, Itumbiara University Unit, Itumbiara, Goiás, Brazil., Carneiro LC; Graduate Program in Health Sciences, Federal University of Goiás, Institute of Tropical Pathology and Public Health, Biotechnology Laboratory of Microorganisms, Federal University of Goiás, Goiânia, Goiás, Brazil. |
| Abstrakt: |
The Quilombola communities are mostly isolated and deprived of sources of treated water, garbage collection and sewage, consuming fresh water from wells, streams, lakes, among others. This lack of basic infrastructure can be a relevant factor in exposing residents to substances and factors that are harmful to the integrity of their genetic material that can lead to carcinogenesis. Based on this, the objective of this study was to evaluate the genomic and mutagenic/cytotoxic damage in the adult population of two Quilombola communities (one urban and another rural region), in the state of Goiás, Brazil. For this purpose, the leukocyte of peripheral blood Comet Assay in 68 individuals and Micronucleus Test from exfoliated buccal cells of oral mucosa in 21 volunteers were performed. The results evidenced genomic damage, especially for the community of Aparecida de Goiânia city, which detected significant values (p < 0.05), for the length of the comet's tail and for of the Olive Tail Moment. In the micronucleus test, significant differences were only detected (p < 0.05), when it came to the distribution of nuclear changes among the groups. Therefore, it is essential to perform constant population biomonitoring studies to help guarantee health and, consequently, the quality of life. |
